Guaranteed wellness with
enhanced absorption and availability

Eva – Vitamin-E TPGS NF Grade

For Nutraceutical, Pharmaceutical and Personal Care

Vitamin Etpgs

Natural source, water soluble form of Vitamin E. Vitamin E TPGS is widely used as an excipient in drug formulations and is rapidly expanding into the beverage and functional food markets. Structure – property relationship suggests that it uniquely meets the need for enhancing drug solubility, permeability, safety and enhancing the bioavailability.



Emulsifier - TPGS has amphiphilc properties and is therefore used as emulsifier for nutraceuticals and pharmaceuticals (Lehr 2005). Emulsifier for injectable formulations

Drug Delivery System
  • Drug solubilizer – It directly increases the bioavailability and delivery of poorly soluble drugs
  • Protects drugs from crystallization Provide Vitamin E or poorly soluble nutraceuticals in liquid dosage form Reduces drug sensitivity on skin and tissues
  • Acts as a vehicle in semi-dosage form and also for pulmonary (inhalation) dosage form
  • Carrier for wound care and treatment
  • A thermal binder in melt granulations / extrusion process
Absorption enhancer

Vehicle for lipid - based drug delivery - Vitamin E TPGS is an important extension to a range of drug delivery products

Source of natural Vitamin E - used in pharmaceutical formulations as well as dietary supplements Extensively used in solid, topical and ophthalmic dosage forms

Key features of Eva

  • Produced with stringent industry requirements,
  • maintaining GMP conditions
  • Technology driven process to maintain the supply
  • chain
  • Synthesized from natural source of Vitamin E
  • No chlorinated solvents used
  • Complies as per USP
  • Offers high activity and reliable composition

vitamin e tpgs


Amphiphilic (Surface-active) properties

Vitamin E TPGS is amphiphile, that is it has a dual nature. Part of the molecule exhibits hydrophilicity and the other lipophilicity. General accepted view is that the polyethylene glycol portion serves as the hydrophilic polar head (water soluble), while the tocopherol succinate portion serves as the lipophilic alkyl tail (water insoluble).


Vitamin E TPGS is stable when exposed to oxygen, heat, light, or oxidizing agents. It is unstable to alkali. Vitamin E TPGS is known to be stable excipient with a shelf-life of 4 years when stored in the original unopened container at room temperature. Vitamin E TPGS is stable under the conditions of heat sterilization. Stability data will be available soon.

Safety and Toxicology

Regarding the safety of Vitamin E TPGS, various studies have been conducted in the last decades. EFSA (European Food Safety Authority) has conducted studies to assess the safety and bioavailability of Vitamin E TPGS for use in food particularly for nutritional / medical purposes. From toxicology studies, an overall no-observed-adverse-effect level (NOAEL) of 1000 mg / kg body weight per day can be derived. Vitamin E TPGS is not genotoxic. Also approved by US-FDA (United States - Food and Drug Administration).

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